In:
International Journal of Cancer, Wiley, Vol. 137, No. 10 ( 2015-11-15), p. 2374-2383
Kurzfassung:
What's new? The transcription factor HOXB7 is overexpressed in various cancers, but it's not yet known just which genes HOXB7 activates. How does it influence cancer on a molecular level? This study found 1500 sequences where HOXB7 binds the chromatin in breast cancer cells. They went on to identify several potential target genes near the HOXB7 binding sites. Not only will finding these genes help explain how HOXB7 overexpression promotes tumor growth, it will help understand what side effects might result from hindering HOXB7 expression.
Materialart:
Online-Ressource
ISSN:
0020-7136
,
1097-0215
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2015
ZDB Id:
218257-9
ZDB Id:
1474822-8
