In:
International Journal of Cancer, Wiley, Vol. 137, No. 11 ( 2015-12), p. 2618-2629
Abstract:
What's new? Intraoperative detection of residual tumor is an emerging technique aimed at improving the prognosis of women with ovarian cancer. The authors developed a new system using the carboxy‐terminal fragment of Clostridium Perfringens Enterotoxin (c‐CPE) conjugated to fluorescent fluorophores to successfully mark microscopic tumor deposits in mouse models of chemotherapy‐naïve and chemotherapy‐resistant ovarian cancer. C‐CPE binds to claudin 3/4 receptors, which the authors showed earlier are highly overexpressed on most types of ovarian cancer, thus providing a new tumor‐specific tool to minimize micrometastic disease in patients with ovarian cancer.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8