In:
International Journal of Cancer, Wiley, Vol. 138, No. 7 ( 2016-04), p. 1709-1718
Abstract:
What's new? The heterogeneity of different malignant cell populations within a tumor is a major mechanism of therapeutic resistance in cancer, and in glioblastoma such resistance is a leading obstacle to long‐term survival. This study shows that glioblastoma cell behaviour is more strongly dependent on differentiation status than on genetic identity. Moreover, glioblastoma was found to belong to the group of tumors that readily allow dedifferentiation. The findings significantly impact the direction of future therapeutic strategies for glioblastoma and provide context for recent data on differences in therapeutic resistance between different glioblastoma cell populations.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8