In:
International Journal of Cancer, Wiley, Vol. 139, No. 2 ( 2016-07-15), p. 446-456
Abstract:
What's new? While inflammatory cells are common in the tumor microenvironment, the associations of specific cell types with tumor development and disease progression are unclear. This is true particularly in the case of tumor‐associated neutrophils (TAN), for which previous reports have identified conflicting roles in tumor progression. The present study links TAN density in colorectal cancer (CRC) tissues with patient outcome, indicating that TANs are an important component of tumor‐infiltrating inflammatory cell populations in this disease. The prognostic relevance of TANs in CRC was influenced by disease stage and 5‐fluorouracil‐based chemotherapy, with higher TAN density associated with better therapeutic response.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8