In:
International Journal of Cancer, Wiley, Vol. 139, No. 11 ( 2016-12), p. 2512-2518
Kurzfassung:
What's new? While the number of patients with virus‐related hepatocellular carcinoma (HCC) is expected to decline thanks to advanced anti‐virus therapy, the number of patients with nonalcoholic fatty liver disease‐derived HCC (NAFLD‐HCC) has been raising worldwide due to increased prevalence of metabolic syndrome. The molecular features of NAFLD‐HCC remain to be fully determined. Here, the authors analyzed genetic aberrations in NAFLD‐HCC tumor samples by whole‐exome sequencing, targeted sequencing, and copy number variation studies. Although NAFLD‐HCC shared similar genetic aberration profiles with HCC from other etiologies, TERT promoter mutations and chromosome 8p loss emerged as potentially essential factors in NAFLD‐derived liver carcinogenesis.
Materialart:
Online-Ressource
ISSN:
0020-7136
,
1097-0215
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2016
ZDB Id:
218257-9
ZDB Id:
1474822-8