In:
International Journal of Cancer, Wiley, Vol. 139, No. 11 ( 2016-12), p. 2553-2569
Abstract:
What's new? Several human cancers have been shown to express abnormal levels of voltage‐gated sodium channels (VGSCs). However, the role of these membrane ion channels in gastric cancer (GC) remains unclear. In this study, the authors found that overexpression of VGSC‐Na v 1.7 indicated a poor prognosis for GC patients. It was also correlated with upregulation of NHE1 and MACC1, and overexpression of that pathway increased proliferation of GC cells in mice. VGSC‐Na v 1.7 may thus be a useful prognostic marker in GC, as well as a potential therapeutic target.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8