In:
International Journal of Cancer, Wiley, Vol. 140, No. 4 ( 2017-02-15), p. 853-863
Abstract:
What's new? Many of the genes and pathways that functionally cooperate with deregulated TGF‐β signaling to drive colorectal cancer (CRC) are unknown. Using the Sleeping Beauty mouse model, the authors discovered functionally‐relevant candidate pathways and driver genes that mediate CRC formation in vivo in the setting of TGF‐β receptor inactivation. Most of these genes are novel and the majority were also found to be mutated in human CRCs, demonstrating the relevance of the findings to human primary cancer. The identification of these factors advances our understanding of the molecular pathogenesis of CRC and provides insight into possible treatment options for CRC patients.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8