In:
International Journal of Cancer, Wiley, Vol. 141, No. 11 ( 2017-12), p. 2336-2347
Kurzfassung:
What's new? Cisplatin or carboplatin in combination with another cytotoxic drug has been recommended as first‐line chemotherapy in lung cancer. Platinum agents can however cause cytotoxic effects through their binding with DNA. Genetic variations in DNA repair genes may contribute to the toxicity of platinum‐based chemotherapy, but previous pharmacogenetic studies have been conflicting and inconclusive. Here, the authors performed a multiple‐center, two‐stage analysis to examine the association of 97 SNPs in 54 genes from DNA repair pathways with severe platinum‐induced toxicities. They demonstrated that XPC rs2228000 conferred better tolerance toward severe toxicities. The findings may offer comprehensive pharmacogenetic information for platinum‐induced toxicity.
Materialart:
Online-Ressource
ISSN:
0020-7136
,
1097-0215
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2017
ZDB Id:
218257-9
ZDB Id:
1474822-8