In:
International Journal of Cancer, Wiley, Vol. 143, No. 1 ( 2018-07), p. 212-224
Abstract:
What's new? Epidermal growth factor receptor (EGFR)‐tyrosine kinase inhibitors (TKIs) have shown a radiosensitizing effect in extracranial tumors, suggesting the potential of combining a blood‐brain barrier penetrating agent with radiation as a new therapeutic approach to brain metastasis. This study shows that AZD3759, an EGFR‐TKI with excellent blood‐brain barrier penetration, combined with radiation enhances antitumor efficacy on brain metastasis from EGFR mutant non‐small cell lung cancer (NSCLC) sensitive to AZD3759. AZD3759 with sequential or concurrent radiation achieved comparable efficacy. The results warrant further clinical studies to investigate AZD3759 combined with radiation as a potentially effective treatment for brain metastasis in EGFRm NSCLC.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8