In:
International Journal of Cancer, Wiley, Vol. 143, No. 8 ( 2018-10-15), p. 1896-1903
Abstract:
What's new? How does oxidative stress induce liver cancer? Here, the authors measured urinary levels of 15‐F2t‐isoprostane (15‐F2t‐IsoP), a marker for oxidative stress. Using pre‐diagnosis urine samples, they found higher levels of 15‐F2t‐IsoP in liver cancer patients than in controls. Smoking and drinking alcohol both increased levels of urinary 15‐F2t‐IsoP. In men, smaller amounts of 15‐F2t‐IsoP bumped up liver cancer risk faster than in women, where increased risk occurred only at higher levels. Also, the presence of hepatitis B surface antigen boosted the risk even more, suggesting a synergistic effect between HBV infection and oxidative stress.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8