In:
International Journal of Cancer, Wiley, Vol. 143, No. 11 ( 2018-12), p. 2892-2904
Abstract:
What's new? The functional roles of miR‐134 in malignant transformation are complicated and controversial to date. This study clarifies that miR‐134 targets Programmed Cell Death (PDCD) 7 to drive oncogenicity in oral squamous cell carcinoma. PDCD7 transactivates the expression of E‐cadherin, a head and neck squamous cell carcinoma progression marker, for oral carcinoma suppression. Knockout of PDCD7 increases the nodal metastasis of oral carcinoma xenografts in mouse model. The activation of miR‐134–PDCD7–E‐cad regulatory axis occurs in the early stage of oral carcinogenesis. This work shows the potential of miR‐134 inhibition and PDCD7 induction for oral carcinoma abrogation.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8