In:
International Journal of Cancer, Wiley, Vol. 144, No. 2 ( 2019-01-15), p. 322-333
Abstract:
What's new? Tumor vascularization is a fundamental step in tumor growth and metastasis. In this study, extracellular vesicles (EVs) released from human liver stem‐like cells (HLSC) inhibited migration of tumor endothelial cells and significantly reduced vessel‐like formation in vitro. Experiments performed in vivo in a SCID mouse model of tumor angiogenesis also showed that HLSC‐EVs were able to inhibit vessel formation and growth. This effect appeared to be specific to HLSC‐EVs, as bone marrow‐derived mesenchymal stem cells EVs displayed no effect. In addition, this anti‐angiogenic feature of HLSC‐EVs was mediated by transfer of specific anti‐angiogenic miRNAs and down‐regulation of predicted target genes.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8