In:
International Journal of Cancer, Wiley, Vol. 144, No. 4 ( 2019-02-15), p. 730-740
Abstract:
What's new? The Women's Health Initiative discovered that women taking conjugated equine estrogens (CEE) and medroxyprogesterone acetate (MPA) together increased their risk of breast cancer, but surprisingly, taking CEE alone reduced the risk of cancer. Here, the authors investigate the mechanism involved. To trace the pathway of CEE metabolism, they measured 15 different estrogen metabolites, using serum from women in the WHI Observational Study. In women taking estrogen alone, they found more activity in the “2‐pathway” over the “16‐pathway” of estrogen metabolism, which leads to reduced cancer risk. Those taking estrogen and progestin together showed more activity in the “16‐pathway,” associated with higher cancer risk.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8