In:
International Journal of Cancer, Wiley, Vol. 145, No. 1 ( 2019-07), p. 58-69
Abstract:
What's new? In ovarian cancer, risk factor profiles may be associated with disease subtypes defined by aggressiveness independent of histology, according to this new analysis. In this large consortium‐based prospective study, the authors classified ovarian tumors according to aggressiveness, based on years between diagnosis and death. They hypothesized that pre‐diagnosis exposure to risk factors, such as smoking, BMI, family history, and pregnancy, would influence whether an ovarian cancer developed on a path toward more aggressive or less aggressive disease. Indeed, in clustering analysis, risk factor associations tracked by tumor aggressiveness rather than histotypes. Smoking and BMI, two modifiable risk factors, were associated with highly aggressive disease.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8