In:
International Journal of Cancer, Wiley, Vol. 145, No. 1 ( 2019-07), p. 87-98
Abstract:
What's new? Lynch‐like syndrome (LLS), characterized by mismatch repair (MMR)‐deficient colorectal tumors that lack MLH1 promoter methylation and germline mutations, remains a diagnostic challenge. Here, LLS was found to account for about 13 percent of MMR‐deficient colorectal carcinomas in patients diagnosed in Central Finland between 2000 and 2010. While LLS tumors could not be reliably distinguished from Lynch syndrome (LS) tumors based on clinical or histological factors, LLS tumors differed significantly from sporadic MLH1 ‐methylated and LS tumors DNA methylation and somatic mutation profiles. The findings provide valuable insight into LLS and could facilitate advances in LLS diagnosis and treatment.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
