In:
International Journal of Cancer, Wiley, Vol. 145, No. 10 ( 2019-11-15), p. 2692-2700
Kurzfassung:
What's new? In the Finnish population, a small number of recurrent mutations account for the majority of deleterious variations in breast and ovarian cancer susceptibility genes. The authors investigated 12 recurrent moderate‐risk mutations in Finnish breast and ovarian cancer patients. These mutations were found with similar frequency in unselected patients and BRCA1/2 ‐positive familial index patients, twice as often as in population controls. In addition, a novel association was identified between breast cancer risk and CHEK2 variant c.319+2T 〉 A. The findings highlight the relevance of gene panel testing for breast and ovarian cancer risk assessment and its potential use for assessing breast cancer families with members who may carry different mutations.
Materialart:
Online-Ressource
ISSN:
0020-7136
,
1097-0215
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2019
ZDB Id:
218257-9
ZDB Id:
1474822-8
