In:
International Journal of Cancer, Wiley, Vol. 147, No. 2 ( 2020-07-15), p. 505-518
Abstract:
What's new? ZIC family members regulate neural development but have also been implicated in the development of various tumors. Here the authors report downregulation of ZIC2 in breast cancer cells. Low expression of ZIC2 correlated with poor outcome in breast cancer patients and served as an independent prognostic marker. The transcription factor STAT3 was identified as a potential target for ZIC2, and inhibition of STAT3 abrogated the oncogenic effects induced by decreased ZIC2 expression. STAT3 inhibitors might provide an alternative option for women with breast cancer showing ZIC2 downregulation.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
