In:
International Journal of Cancer, Wiley, Vol. 147, No. 2 ( 2020-07-15), p. 575-583
Abstract:
What's new? Altered expression of the CEACAM1 adhesion molecule has been linked to adverse tumor features in various cancer types. The role of CEACAM1 in prostate cancer is poorly understood, however. Studying a large set of more than 13,000 cancers, here the authors found that loss of CEACAM1 expression was strongly linked to high Gleason grade, lymph node metastasis, advanced tumor stage, positive surgical margin, frequent genomic deletions, and early biochemical recurrence, especially in ERG‐fusion positive cancers. Furthermore, loss of CEACAM1 expression characterized a subset of tumors with a particularly poor prognosis, independently from established histo‐morphological features, with potential clinical applications.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
