In:
International Journal of Cancer, Wiley, Vol. 147, No. 8 ( 2020-10-15), p. 2150-2158
Abstract:
What's new? DNA mismatch repair deficiency (dMMR) is often found in colorectal cancer (CRC), and can be caused by hereditary Lynch syndrome (LS). In this study, the authors found that, in CRC patients younger than age 65, LS is common enough that both dMMR and germline testing are warranted. In patients older than age 64, however, non‐heritable causes of dMMR are 20‐fold more common than LS. It is thus reasonable to restrict germline testing to dMMR‐CRC patients who are below age 65.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
