In:
International Journal of Cancer, Wiley, Vol. 148, No. 5 ( 2021-03), p. 1260-1275
Abstract:
What's new? Gastroesophageal adenocarcinoma patients with high microsatellite instability tumors present with a distinct phenotype and good response to immunotherapy. However, little is known about the immunogenic phenotype of low microsatellite instability (MSI‐L) tumors. Here, the authors show that, compared to gastroesophageal adenocarcinoma microsatellite stable tumors, MSI‐L tumors have significantly higher indel mutational burden, higher levels of intratumoral CD8+ cell infiltration, and favorable outcomes. The findings suggest a distinct immunogenic phenotype for MSI‐L tumors and the potential to also treat this gastroesophageal adenocarcinoma subtype by immunotherapy.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8