In:
International Journal of Cancer, Wiley, Vol. 148, No. 7 ( 2021-04), p. 1616-1624
Abstract:
What's new? Myeloproliferative neoplasms (MPN) are a rare and heterogeneous group of diseases, and the genetic susceptibility is still not well understood. Several cases have been reported of patients with both MPN and multiple myeloma (MM). These authors tested whether MPN and MM have overlapping genetic susceptibility loci. They analyzed 23 known MM risk loci in participants from a case‐control study of MPN, including 460 cases and 880 controls. While no individual SNP reached statistical significance, a polygenic risk score showed an association with MPN risk, suggesting that several MM risk loci in combination could influence the risk of MPN.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8