In:
International Journal of Cancer, Wiley, Vol. 148, No. 12 ( 2021-06-15), p. 2997-3007
Abstract:
What's new? Ulcerative colitis‐associated colorectal carcinoma (CA‐CRC) is a complex disease involving inflammation‐associated tumorigenesis and genetic mutation. Despite extensive knowledge of germline defects linked to CA‐CRC, however, molecular pathogenesis of the disease remains poorly defined. In this study, using tumor profiling, the authors describe three genetic and epigenetic CA‐CRC subgroups, two of which are previously known and one that is novel. The novel subgroup consisted of hypermutated microsatellite‐stable tumors, which displayed distinct mutational signatures compared to the remaining CA‐CRC subgroups and Lynch syndrome tumors, suggesting pathophysiologic differences. The existence of molecular subgroups within CA‐CRCs may inform treatment decisions.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8