In:
International Journal of Cancer, Wiley, Vol. 148, No. 12 ( 2021-06-15), p. 3071-3085
Abstract:
What's new MicroRNAs have shown potential in the diagnosis, treatment, and prognosis of hematological malignancies. Here, the authors found that miR‐17‐3p is highly expressed in the plasma and bone marrow cells of multiple myeloma patients. miR‐17‐3p expression is positively correlated with diagnostic indexes as well as the stage of disease. Moreover, miR‐17‐3p exerts an oncogenic role by regulating the proliferation, apoptosis, cell cycle, and colony formation of multiple myeloma cells by targeting LMLN and regulating P21. Altogether, the results identify miR‐17‐3p as a promising diagnostic biomarker and unveil the role of the miR‐17‐3p‐LMLN‐P21 axis in multiple myeloid progression.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8