In:
International Journal of Cancer, Wiley, Vol. 149, No. 8 ( 2021-10-15), p. 1585-1592
Kurzfassung:
What's new? Dual blockade of the human epidermal growth factor receptor 2 (HER2) with trastuzumab and pertuzumab is the preferred option for neoadjuvant systemic therapy (NST) against node‐positive, HER2‐positive breast cancer. Whether this approach effectively improves pathologic complete response (pCR), however, remains unclear. Here, comparison of pCR for single or dual HER2 blockade shows that trastuzumab effectively increases axillary pCR rate in clinically node‐positive, HER2‐positive breast cancer. The addition of pertuzumab to trastuzumab did not further elevate pCR rate. The findings are relevant to decisions regarding axillary surgery in breast cancer patients with pCR after NST with HER2 targeted agents.
Materialart:
Online-Ressource
ISSN:
0020-7136
,
1097-0215
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2021
ZDB Id:
218257-9
ZDB Id:
1474822-8
