In:
International Journal of Cancer, Wiley, Vol. 150, No. 1 ( 2022-01), p. 56-66
Kurzfassung:
What's new? While associations between colorectal cancer (CRC) risk and Lynch syndrome (LS) are well‐described, less is known about CRC risks linked to the closely related Lynch‐like syndrome (LLS) and familial colorectal cancer type X (FCCX). In this prospective follow‐up study of patients with LS, LLS, and FCCX, risks were similar for colorectal adenomas but considerably different for first and metachronous CRCs. In addition, LS females who carried MSH2 mutations had notably higher CRC risks than female MLH1 mutation carriers. The identification of variations in carcinogenic pathways between LS, LLS, and FCCX could enable risk‐adapted CRC surveillance for these syndromes.
Materialart:
Online-Ressource
ISSN:
0020-7136
,
1097-0215
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2022
ZDB Id:
218257-9
ZDB Id:
1474822-8