In:
International Journal of Cancer, Wiley, Vol. 150, No. 4 ( 2022-02-15), p. 626-635
Abstract:
What's new? For patients with nonsmall cell lung cancer (NSCLC), epidermal growth factor tyrosine kinase inhibitors (EGFR‐TKIs) can significantly improve survival. EGFG‐TKI effectiveness, however, is compromised by acquired EGFR mutations, especially de novo T790M mutations. Here, the impact of EGFR genotypes on the efficacy of afatinib, a second‐generation EGFR‐TKI, was investigated in a cohort of EGFR ‐mutated NSCLC patients. Afatinib efficacy was associated with T790M allele quantity in patients with de novo T790M mutation. In particular, front‐line afatinib therapy was associated with favourable survival in EGFR ‐mutated patients, whereas resistance was marked by a genotype‐specific pattern of disease progression, with secondary T790M development.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8