In:
Israel Journal of Chemistry, Wiley, Vol. 59, No. 5 ( 2019-05), p. 439-445
Abstract:
A new indoleglycerol, designated as arecine ( 1 ), and twenty‐three known diketopiperazines 2 – 24 were isolated from the endophytic fungus Diaporthe arecae associated with mangrove Kandelia obovate . Structures of all secondary metabolites 1 – 24 were identified on the basis of their spectrometric data, especially the nuclear magnetic resonance, optical rotation, and mass data. The absolute stereochemistry of compound 1 was determined by comparing its experimental electronic circular dichroism spectrum to those of in silico generated. Moreover, the 1 H and 13 C NMR spectroscopic data of isolated diketopiperazines 3 – 24 were measured in dimethyl sulfoxide‐ d 6 and presented in Table 2 for a convenient comparison. Pharmacological study showed cordysinin A ( 2 ) possessed mild anti‐angiogenic activity, which suppressed tube formation with an IC 50 value of 15.1±0.2 μg/mL.
Type of Medium:
Online Resource
ISSN:
0021-2148
,
1869-5868
DOI:
10.1002/ijch.201800158
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2066481-3