In:
Journal of Applied Toxicology, Wiley, Vol. 38, No. 10 ( 2018-10), p. 1323-1335
Abstract:
The marked differences in bile acid (BA) composition between preclinical safety models and humans may play a major role in the poor prediction of drug‐induced liver injury. We compared the composition of plasma and urinary BAs and their metabolites between humans and several animal species. BA profiles varied widely among different species and it comprised primarily hydrophilic and less toxic BAs in mice, rat, pig and hamster, while it primarily comprised hydrophobic and more toxic BAs in human, rabbit and chimpanzee. In general, BA profiles of chimpanzee and monkeys were most similar to humans, while minipig, rat and mice were most dissimilar to humans.
Type of Medium:
Online Resource
ISSN:
0260-437X
,
1099-1263
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1475015-6