In:
Journal of Applied Toxicology, Wiley, Vol. 41, No. 3 ( 2021-03), p. 470-482
Kurzfassung:
We performed an in vitro toxicity test and pulmonary toxicity studies using human lung epithelial cells and Sprague–Dawley (SD) rats to evaluate the toxicity of cetylpyridinium chloride (CPC), one of quaternary ammonium compounds (QACs). The results demonstrated that CPC is highly cytotoxic. Intratracheal instillation of CPC induced multifocal inflammation of the pulmonary parenchyma, with corresponding increases in several inflammatory‐related cytokines and polymorphonuclear leukocyte (PMN) levels. These results suggested that CPC could induce inflammation, which leads to fibrosis of the pulmonary system.
Materialart:
Online-Ressource
ISSN:
0260-437X
,
1099-1263
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2021
ZDB Id:
1475015-6