In:
Journal of Applied Toxicology, Wiley, Vol. 42, No. 5 ( 2022-05), p. 806-817
Abstract:
Perfluorooctane sulfonate (PFOS) is strongly accumulated in the liver following chronic exposure and may facilitate the progression of liver diseases. This study found that PFOS exposure may promote the activation of NLR pyrin domain containing 3 (NLRP3) inflammasome to drive hepatocyte pyroptosis. Through activating NLRP3 inflammasome, PFOS induces the release of pro‐inflammatory cytokines and may facilitate steatosis in a high‐fat diet (HFD) mouse model. Our findings indicate a prosteatotic effect of PFOS via NLRP3 inflammasome activation and pyroptosis.
Type of Medium:
Online Resource
ISSN:
0260-437X
,
1099-1263
Language:
English
Publisher:
Wiley
Publication Date:
2022
detail.hit.zdb_id:
1475015-6