In:
Journal of Clinical Apheresis, Wiley
Abstract:
Vasovagal reactions (VVRs) are the most common adverse reactions and are frequently associated with serious donor adverse events. Even mild VVRs can lead to a significant reduction in the likelihood of subsequent donations. The purpose of this study is to explore the factors related to the occurrence of VVRs after plasma donation and to construct a nomogram to identify individuals at risk for VVRs to improve the safety of plasma donors. Materials and Methods We collected the donation data from July 2019 to June 2020 from a plasma center in Sichuan, China, to explore the independent risk factors for vasovagal reactions. From these data, we constructed and validated a predictive model for vasovagal reactions. Results VVRs after plasma donation occurred 737 times in 120 448 plasma donations (0.66%). Gender, season, donor status, weight, pulse, duration of donation, and cycle were independent risk factors for VVRs ( P 〈 0.05). The concordance index (C‐index) of a logistic model in the derivation cohort was 0.916, with a Hosmer‐Lemeshow goodness‐of‐fit probability of 0.795. The C‐index of a logistic model in the validation cohort was 0.916, with a Hosmer‐Lemeshow goodness‐of‐fit probability of 0.224. The calibration curve showed that the predicted results were in good agreement with the actual observed results. Conclusion This study preliminarily constructed and verified a prediction model for VVRs after plasma donation. The model nomogram is practical and can identify high‐risk donors.
Type of Medium:
Online Resource
ISSN:
0733-2459
,
1098-1101
Language:
English
Publisher:
Wiley
Publication Date:
2023
detail.hit.zdb_id:
2001633-5
