In:
Journal of Clinical Laboratory Analysis, Wiley, Vol. 32, No. 3 ( 2018-03)
Abstract:
The 99th percentile of cardiac troponin I level in the general population is accepted as the cut‐off for the diagnosis of acute myocardial infarction ( AMI ). However, it is not clear whether the cut‐offs derived in racially and geographically different populations are applicable in Japan. Methods Troponin I was determined using the Abbott ARCHITECT STAT high‐sensitive troponin I immunoassay in 698 apparently healthy individuals who visited the Japanese Red Cross Medical Center for a health checkup. Results The 99th percentile of the hsTnI in the overall population was 22.5 (95% confidence interval ( CI ), 16.8‐36.6) pg/ mL , 17.7 (95% CI 12.0‐22.8) pg/ mL for females and 30.6 (95% CI 17.1‐53.4) pg/ mL for males. The median of the hsTnI in the overall population was 3.2 (95% CI , 3.0‐3.3) pg/ mL , 2.6 (95% CI 2.4‐2.8) pg/ mL for females and 4.0 (95% CI 3.8‐4.3) pg/ mL for males. The age and gender had a significant influence on these values. The troponin I level also showed significant associations with the body mass index (BMI), the gamma glutamyl transferase ( GGT ), lactate dehydrogenase ( LDH ), estimated glomerular filtration rate ( eGFR ), and cardiac abnormalities by electrocardiography ( ECG ) but not with the high‐sensitive C‐reactive protein (hsCRP) level. Conclusions The 99th percentiles of the troponin I measured in the general population in Japan were comparable as the ones derived in the US , Germany, and Singapore. The troponin I level was dependent on the gender, age, BMI, and cardiac abnormalities found by ECG but not by the hs CRP level.
Type of Medium:
Online Resource
ISSN:
0887-8013
,
1098-2825
DOI:
10.1002/jcla.2018.32.issue-3
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2001635-9