In:
Journal of Clinical Laboratory Analysis, Wiley, Vol. 32, No. 7 ( 2018-09)
Kurzfassung:
The aim of our study was to investigate the correlation between serum carbohydrate antigen 153 ( CA 153) and renal function in patients with type 2 diabetes mellitus (T2 DM ). Methods A total of 184 patients with T2 DM were included, and renal function was assessed by the modification of diet in renal disease ( MDRD ) formula adjusted coefficient of the Chinese people. Results Serum CA 153 concentrations were positively correlated with blood glucose ( BG ) and glycated hemoglobin (HbA1c) ( r = .204, P = .005; r = .165, P = .025) in patients with T2 DM . There was a negative correlation between serum CA 153 and estimated glomerular filtration rate (GFR) ( r = −.229, P = .002) in whole patients with T2 DM ; similarly, the correlations were observed in both women and men ( r = −.228, P = .028 for women, r = −.231, P = .028 for men). Multiple linear regression analysis suggested that serum CA 153 was still significantly correlated with estimated GFR (beta = −0.286, P 〈 .001). Conclusions Serum CA 153 is negatively correlated with estimated GFR in patients with T2 DM , and serum CA 153 may be a potentially useful clinical biomarker to assess renal function in the study population.
Materialart:
Online-Ressource
ISSN:
0887-8013
,
1098-2825
DOI:
10.1002/jcla.2018.32.issue-7
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2018
ZDB Id:
2001635-9
