In:
Journal of Cellular Physiology, Wiley, Vol. 213, No. 3 ( 2007-12), p. 826-833
Abstract:
The toxic effects of exogenous hydrogen sulfide on peripheral blood lymphocytes have been investigated in detail. Hydrogen sulfide is now considered as a gasotransmitter with specific functional roles in different cell types, like neurons and vascular smooth muscle. Here we show that exogenous hydrogen sulfide induces a caspase‐independent cell death of peripheral blood lymphocytes that depends on their intracellular glutathion levels, with a physiologically relevant subset specificity for CD8 + T cells and NK cells. Although lymphocyte activation does not modify their sensitivity to HS − , after 24 h exposure to hydrogen sulfide surviving lymphocyte subsets show a dramatically decreased proliferation in response to mitogens and a reduced IL‐2 production. Overall, our data demonstrate that HS − reduces the cellular cytotoxic response of peripheral blood lymphocytes as well as their production of IL‐2, therefore de‐activating the major players of local inflammatory responses, adding new basic knowledge to the clinically well known anti‐inflammatory effects of sulfur compounds. J. Cell. Physiol. 213:826–833. © 2007 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
0021-9541
,
1097-4652
Language:
English
Publisher:
Wiley
Publication Date:
2007
detail.hit.zdb_id:
1478143-8
SSG:
12