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Altering chromatin methylation patterns and the transcriptional network involved in regulation of hematopoietic stem cell fate

Shokouhian, Mohammad ; Bagheri, Marziye ; Poopak, Behzad ; [weitere]

Wiley ; 2020

In: Journal of Cellular Physiology Vol. 235, No. 10 ( 2020-10), p. 6404-6423

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In: Journal of Cellular Physiology, Wiley, Vol. 235, No. 10 ( 2020-10), p. 6404-6423

Kurzfassung: Chromatin methylation and transcriptional network are involved in the regulation of the balance between self‐renewal and differentiation of hematopoietic stem cells (HSCs). There is a link between aberrant chromatin methylation and transcriptional factors related to the maintenance of HSCs and dysregulation of gene expression. Dysregulation of HSCs gene expression could be related to leukemic transformation.

Materialart: Online-Ressource

ISSN: 0021-9541 , 1097-4652

URL: Issue

URL: Article

DOI: 10.1002/jcp.v235.10

DOI: 10.1002/jcp.29642

Sprache: Englisch

Verlag: Wiley

Publikationsdatum: 2020

ZDB Id: 1478143-8

SSG: 12