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Reverted effect of mesenchymal stem cells in glioblastoma treated with agathisflavone and its selective antitumoral effect on cell viability, migration, and differentiation via STAT3

Nascimento, Ravena P. ; dos Santos, Balbino L. ; da Silva, Karina C. ; [et al.]

Wiley ; 2021

In: Journal of Cellular Physiology Vol. 236, No. 7 ( 2021-07), p. 5022-5035

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In: Journal of Cellular Physiology, Wiley, Vol. 236, No. 7 ( 2021-07), p. 5022-5035

Abstract: Flavonoid agathisflavone selective induces dose‐dependent toxicity in GL‐15 and U373 human glioblastoma (GBM) cells. Agathisflavone inhibits migration and promotes differentiation of human GBM cells. Agathisflavone is not toxic to human mesenchymal stem cells but modifies the pattern of interaction with glioblastoma cells, resulting in resistance.

Type of Medium: Online Resource

ISSN: 0021-9541 , 1097-4652

URL: Issue

URL: Article

DOI: 10.1002/jcp.v236.7

DOI: 10.1002/jcp.30209

Language: English

Publisher: Wiley

Publication Date: 2021

detail.hit.zdb_id: 1478143-8

SSG: 12