In:
Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 42, No. 5 ( 1987-11-01), p. 463-473
Kurzfassung:
Induction of luminol-enhanced chemiluminescence (CL) indicative of reactive oxygen formation was studied in glia cell cultures from newborn mice. A burst of CL could be induced by phorbol myristate acetate, zymosan, and antibody-coated bovine red blood cells, whereas Sendai virus and several other agents known to induce CL in myeloid cells were ineffective. Sodium azide failed to inhibit CL, indicating a myeloperoxidase-independent mechanism of light emission. In parallel experiments we identified the cells binding antibody-coated erythrocytes as macrophages characterized by the reduction of nitroblue tetrazolium and phagocytosis of zymosan and latex particles. Brain macrophages may use reactive oxygen intermediates (ROI) as a mechanism of antimicrobial defence; and, on the other hand, ROI formed by these cells may contribute to immunopathology in the brain.
Materialart:
Online-Ressource
ISSN:
0741-5400
,
1938-3673
DOI:
10.1002/jlb.42.5.463
Sprache:
Englisch
Verlag:
Oxford University Press (OUP)
Publikationsdatum:
1987
ZDB Id:
2026833-6
SSG:
12