In:
Journal of Labelled Compounds and Radiopharmaceuticals, Wiley, Vol. 49, No. 3 ( 2006-03-15), p. 287-293
Kurzfassung:
Although 3′‐deoxy‐3′‐[ 18 F]fluorothymidine ([ 18 F]FLT) is a prospective radiopharmaceutical for the imagi ng of proliferating tumor cell, it is difficult to prepare large amount of [ 18 F]FLT. We herein describe the preparation of [ 18 F]FLT in an ionic liquid, [bmim] [OTf] (1‐butyl‐3‐methyl‐imidazolium trifluoromethanesulfonate). At optimized condition, [ 18 F]fluorinationin ionic liquid with 5 µl of 1 M KHCO 3 and 5 mg of the precursor yielded 61.5 ± 4.3% ( n =10). Total elapsed time was about 70 min including HPLC purification. The rapid synthesis of [ 18 F]FLT can be achieved by removing all evaporation steps. Overall radiochemical yield and radiochemical purity were 30 ± 5% and 〉 95%, respectively. This method can use a small amount of a nitrobenzenesulfonate precursor and can be adapted for automated production. Copyright © 2006 John Wiley & Sons, Ltd.
Materialart:
Online-Ressource
ISSN:
0362-4803
,
1099-1344
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2006
ZDB Id:
1491841-9
SSG:
15,3
