In:
Journal of Molecular Recognition, Wiley, Vol. 28, No. 2 ( 2015-02), p. 117-123
Abstract:
Y‐box binding protein 1 (YB‐1) is widely known to participate in a multiple DNA and RNA processing events in the living cell. YB‐1 is also regarded as a putative component of DNA repair. This possibility is supported by relocalization of YB‐1 into the nucleus following genotoxic stress. Increased affinity of YB‐1 for damaged DNA, especially in its single‐stranded form, and its functional interaction with proteins responsible for the initiation of apurinic/apyrimidinic (AP) site repair, namely, AP endonuclease 1 and DNA glycosylase NEIL1, suggest that YB‐1 could be involved in the repair of AP sites as a regulatory protein. Here we show that YB‐1 has a significant inhibitory effect on the cleavage of AP sites located in single‐stranded DNA and in DNA bubble structures. Such interference may be considered as a possible mechanism to prevent single‐stranded intermediates of DNA replication, transcription and repair from being converted into highly genotoxic DNA strand breaks, thus allowing the cell to coordinate different DNA processing mechanisms. Copyright © 2015 John Wiley & Sons, Ltd.
Type of Medium:
Online Resource
ISSN:
0952-3499
,
1099-1352
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
1491198-X
SSG:
12