In:
Journal of Magnetic Resonance Imaging, Wiley, Vol. 39, No. 4 ( 2014-04), p. 866-871
Kurzfassung:
To evaluate the repeatability of MRI‐derived relative blood volume (RBV) measurements in mouse kidneys across subjects and days and to evaluate sensitivity of this approach to renal pathology. Materials and Methods A 7 Tesla MRI system and an intravascular iron‐oxide contrast agent were used to acquire spin‐echo–based renal RBV maps in 10 healthy mice on 2 consecutive days. Renal RBV maps were also acquired in the Alport and unilateral ureteral obstruction mouse models of renal disease. Results The average renal RBV measured on consecutive days was 19.97 ± 1.50 and 19.86 ± 1.62, yielding a concordance correlation coefficient of 0.94, indicating that this approach is highly repeatable. In the disease models, the RBV values were regionally dissimilar and substantially lower than those found in control mice. Conclusion In vivo renal iron‐oxide–based RBV mapping in mice complements the physiological information obtained from conventional assays of kidney function and could shed new insights into the pathological mechanisms of kidney disease. J. Magn. Reson. Imaging 2014;39:866–871. © 2013 Wiley Periodicals, Inc .
Materialart:
Online-Ressource
ISSN:
1053-1807
,
1522-2586
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2014
ZDB Id:
1497154-9
