In:
Journal of Magnetic Resonance Imaging, Wiley, Vol. 40, No. 2 ( 2014-08), p. 457-466
Abstract:
To evaluate the diagnostic accuracy of dynamic‐contrast–enhanced (DCE) MRI in comparison to both 18 F‐FDG‐ and 68 Ga‐DOTATATE‐PET/CT in patients with liver metastases of neuroendocrine neoplasms (NEN). Materials and Methods Thirty‐two patients with hepatic metastases from NEN were examined both in DCE‐MRI and positron emission tomography/computed tomography (PET/CT), using either 18 F‐fluorodeoxyglucose ( 18 F‐FDG) or 68 Ga‐DOTATATE as tracer. DCE‐MRI was performed at 3 Tesla with Gd‐EOB‐DTPA acquiring 48 slices every 2.2 s for 5 min. Three regions of interest (ROIs) representing liver background and liver metastases were defined in fat‐saturated T1w three‐dimensional GRE MRI sequences in the hepatobiliary phase. Corresponding ROIs were then defined in the DCE‐MRI‐ and in the PET/CT‐dataset. Area under the curve (AUC) was calculated for the differentiation between metastases and liver background for DCE‐MRI and PET‐CT parameters. Results AUC was very high for SUV mean (mean standardized uptake value) derived from 68 Ga‐DOTATATE‐ (AUC = 0.966), and 18 F‐FDG‐PET/CT (AUC = 0.989). For DCE‐MRI parameters, arterial flow fraction and intracellular uptake fraction showed the highest AUCs (AUC = 0.826, AUC = 0.819, respectively). The combination of those two had an AUC of 0.949. The combination of DCE‐MRI and PET‐CT parameters resulted in the highest AUC. Conclusion Both PET/CT parameters and DCE‐MRI perfusion parameters show a high diagnostic accuracy in the distinction between liver metastases and liver tissue. Our data suggest that both modalities provide complementary information. J. Magn. Reson. Imaging 2014;40:457–466 . © 2013 Wiley Periodicals, Inc .
Type of Medium:
Online Resource
ISSN:
1053-1807
,
1522-2586
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
1497154-9
