In:
Journal of Magnetic Resonance Imaging, Wiley, Vol. 42, No. 6 ( 2015-12), p. 1666-1678
Abstract:
To evaluate apparent diffusion coefficient (ADC) histogram parameters that show correlations with prognostic factors and subtypes of breast cancer. Materials and Methods At 3.0T, various ADC histogram parameters were calculated including the entire tumor volume in 173 invasive ductal carcinomas: the minimum, 10th percentile, mean, median, 90th percentile, and maximum. ADC parameters were correlated with prognostic factors and subtype. Results The mean ADC median value was significantly higher in the group with lymph node metastasis, HER2 positivity, and a Ki‐67 value 〈 14% than in the group with negativity for lymph node metastasis, HER2 negativity, and a Ki‐67 value ≥14% (0.907, 0.978, and 0.941 vs. 0.735, 0.778, and 0.761 × 10 −3 mm 2 /s, respectively) ( P 〈 0.01). There was no significant correlation between ADC median and tumor size, histologic grade, estrogen receptor expression, and progesterone receptor expression ( P = 0.272, 0.113, 0.261, and 0.181, respectively). For most ADC parameters except for ADC min , the mean of variable ADC parameters of HER2‐positive, luminal A, luminal B‐HER2(+), triple‐negative, and luminal B‐HER2(–) diseases were arranged in descending order (1.175, 0.936, 0.863, 0.811, and 0.665 × 10 −3 mm 2 /s in ADC median , respectively) with statistical significant difference ( P 〈 0.001). In multivariate analysis, histologic grade, the Ki‐67 index, and HER2 expression were statistically significant explanatory prognostic factors for ADC median and the Ki‐67 index had the most robust effects on ADC parameters (standardized coefficient = –0.317). Conclusion Various ADC parameters were correlated with prognostic factors and subtype, except for ADC min . HER2 positivity showed high ADC values and high Ki‐67 index revealed low ADC values. J. MAGN. RESON. IMAGING 2015;42:1666–1678.
Type of Medium:
Online Resource
ISSN:
1053-1807
,
1522-2586
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
1497154-9
