In:
Journal of Magnetic Resonance Imaging, Wiley, Vol. 48, No. 1 ( 2018-07), p. 160-168
Abstract:
Rotator cuff tendons (RCTs) are challenging to image due to the “magic angle effect” and their short T 2 . Purpose To assess the degree of magic angle sensitivity of human RCTs and to utilize a 3D ultrashort echo time Cones sequence with magnetization transfer preparation (UTE‐Cones‐MT) and two‐pool quantitative MT modeling with histological correlation. We hypothesized that MT parameters would be less sensitive to the magic angle compared with conventional T 2 measurements. Study Type Prospective imaging pathologic correlation. Specimen Twenty cadaveric rotator cuff tendons were imaged at five sample orientations ranging from 0–90° relative to the B 0 field. Field Strength/Sequence 3T/3D UTE‐Cones‐MT and Carr–Purcell–Meiboom–Gill (CPMG). Assessment Two‐pool quantitative MT modeling parameters and T 2 values were calculated in regions of interest drawn by a medical physicist. Histopathological analysis was performed and mild and severe tendinopathy groups were assigned by a histopathologist and histotechnician. Statistical Tests Coefficients of variations (CVs) were calculated for measures between the different orientations and group means were compared for each measure. Results CVs of T 2 and macromolecular fractions between orientations were 26.14 ± 16.82% and 6.18 ± 2.77% (mean ± SD), respectively. T 2 measurements at 0°, 27°, 70°, and 90° showed significant differences between the two histological groups ( P = 0.004, 0.008, 0.003, and 0.015, respectively), but not at 55° ( P = 0.611). Mean T 2 value ranges between orientations for the mild and severe tendinopathy groups were 15.27–30.32 msec and 20.81–35.85 msec, respectively, showing overlap despite statistically significant differences ( P = 0.003). Macromolecular fractions at all angles showed significant differences between the two groups ( P 〈 0.0001). Mean fraction ranges between orientations for the mild and severe tendinopathy groups were 14.32–17.17% and 10.00–13.75% respectively ( P 〈 0.0001) with no overlap. Data Conclusion Compared with T 2 , macromolecular fraction obtained with the 3D UTE‐Cones‐MT technique is resistant to the magic angle effect and is more sensitive to RCT degeneration. Level of Evidence : 1 Technical Efficacy : Stage 2 J. Magn. Reson. Imaging 2017.
Type of Medium:
Online Resource
ISSN:
1053-1807
,
1522-2586
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
1497154-9
