In:
Journal of Magnetic Resonance Imaging, Wiley, Vol. 53, No. 2 ( 2021-02), p. 577-584
Abstract:
Chronic pancreatitis (CP) can result in persistent damage to the endocrine and exocrine tissues of the pancreas. There is an unmet need for quantitative methods to evaluate CP noninvasively. Purpose To investigate the utility of T 1 ρ magnetic resonance imaging (MRI) for the assessment of CP. Study Type Prospective. Population Twenty patients with CP and 24 healthy volunteers. Field Strength/Sequence 3T MRI including T 1 ρ sequence (spin lock time = 0, 1, 10, 20, 40, 60 msec). Assessment Pancreatic T 1 ρ values and anterior–posterior (AP) diameters in the head, body, and tail were measured in all participants. Regions of interest with circle (ROI circle ) and free‐hand (ROI FH ) were drawn for T 1 ρ value measurements. Statistical Tests Mann–Whitney U ‐test; Wilcoxon Signed Ranks test; receiver operating characteristic (ROC) curve; and Bland–Altman analysis. Results The T 1 ρ values of pancreatic tail and the mean T 1 ρ values for ROI circle and the T 1 ρ values of pancreatic tail for ROI FH in patients with CP were significantly higher than those in healthy volunteers (all P 〈 0.05). Pancreatic head AP diameter significantly increased, while pancreatic tail AP diameter significantly decreased in patients with CP compared with healthy volunteers (both P 〈 0.05). The areas under the ROC curves (AUCs) of pancreatic tail T 1 ρ values with ROI circle and tail AP diameter in diagnosing CP were 0.744 and 0.798, respectively. A combination of pancreatic tail T 1 ρ values with ROI circle and tail AP diameter achieved good performance for diagnosing CP (AUC = 0.838). Data Conclusion T 1 ρ MRI might be a potential technique for the noninvasive evaluation of CP. Level of Evidence 2 Technical Efficacy Stage 2 J. MAGN. RESON. IMAGING 2021;53:577–584.
Type of Medium:
Online Resource
ISSN:
1053-1807
,
1522-2586
Language:
English
Publisher:
Wiley
Publication Date:
2021
detail.hit.zdb_id:
1497154-9
