In:
Journal of Magnetic Resonance Imaging, Wiley, Vol. 54, No. 5 ( 2021-11), p. 1562-1571
Kurzfassung:
There is a clinical need for imaging‐derived biomarkers for the management of chronic obstructive pulmonary disease (COPD). Observed pulmonary T 1 (T 1 (TE)) depends on the echo‐time (TE) and reflects regional pulmonary function. Purpose To investigate the potential diagnostic value of T 1 (TE) for the assessment of lung disease in COPD patients by determining correlations with clinical parameters and quantitative CT. Study Type Prospective non‐randomized diagnostic study. Population Thirty COPD patients (67.7 ± 6.6 years). Data from a previous study (15 healthy volunteers [26.2 ± 3.9 years) were used as reference. Field Strength/Sequence Study participants were examined at 1.5 T using dynamic contrast‐enhanced three‐dimensional gradient echo keyhole perfusion sequence and a multi‐echo inversion recovery two‐dimensional UTE (ultra‐short TE) sequence for T 1 (TE) mapping at TE 1‐5 = 70 μsec, 500 μsec, 1200 μsec, 1650 μsec, and 2300 μsec. Assessment Perfusion images were scored by three radiologists. T 1 (TE) was automatically quantified. Computed tomography (CT) images were quantified in software (qCT). Clinical parameters including pulmonary function testing were also acquired. Statistical Tests Spearman rank correlation coefficients ( ρ ) were calculated between T 1 (TE) and perfusion scores, clinical parameters and qCT. A P ‐value 〈 0.05 was considered statistically significant. Results Median values were T 1 (TE 1‐5 ) = 644 ± 78 msec, 835 ± 92 msec, 835 ± 87 msec, 831 ± 131 msec, 893 ± 220 msec, all significantly shorter than previously reported in healthy subjects. A significant increase of T 1 was observed from TE 1 to TE 2 , with no changes from TE 2 to TE 3 ( P = 0.48), TE 3 to TE 4 ( P = 0.94) or TE 4 to TE 5 ( P = 0.02) which demonstrates an increase at shorter TEs than in healthy subjects. Moderate to strong Spearman's correlations between T 1 and parameters including the predicted diffusing capacity for carbon monoxide (DLCO, ρ 〈 0.70), mean lung density (MLD, ρ 〈 0.72) and the perfusion score ( ρ 〉 −0.69) were found. Overall, correlations were strongest at TE 2 , weaker at TE 1 and rarely significant at TE 4 ‐TE 5 . Data Conclusion In COPD patients, the increase of T 1 (TE) with TE occurred at shorter TEs than previously found in healthy subjects. Together with the lack of correlation between T 1 and clinical parameters of disease at longer TEs, this suggests that T 1 (TE) quantification in COPD patients requires shorter TEs. The TE‐dependence of correlations implies that T 1 (TE) mapping might be developed further to provide diagnostic information beyond T 1 at a single TE. Level of Evidence 2 Technical Efficacy Stage 1
Materialart:
Online-Ressource
ISSN:
1053-1807
,
1522-2586
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2021
ZDB Id:
1497154-9
