In:
Journal of Medical Virology, Wiley, Vol. 89, No. 10 ( 2017-10), p. 1817-1822
Kurzfassung:
Some international guidelines recommend evaluating the need to confirm positive anti‐hepatitis C virus (HCV) antibody screening results by means of a more specific antibody or molecular biology test on the basis of a screening threshold value (such as the sample signal/cut‐off ratio) that can predict the positivity of additional antibody testing in at least 95% of cases. The aim of this study was to determine the threshold value of the DiaSorin LIAISON XL chemiluminescence test. Two hundred and twenty‐eight routine laboratory samples that were chemiluminescence positive for anti‐HCV antibodies but had different signal/cut‐off ratios were assayed using immunoblotting, which indicated that 155 (68.0%) were positive, 40 (17.5%) were negative, and 33 (14.5%) were indeterminate. When the samples were divided on the basis of their signal/cut‐off ratios, 95.5% of the samples with a ratio of ≥3.5 were positive as against 74.1% of the positive or indeterminate samples with a ratio of 〈 3.5. Statistical analysis using Youden's index and a receiver operating characteristic curve showed that the optimum cut‐off value was 3.65. These findings indicate that, when using the LIAISON XL system for anti‐HCV antibody screening, a signal/cut‐off ratio of ≥3.65 makes further confirmatory tests unnecessary.
Materialart:
Online-Ressource
ISSN:
0146-6615
,
1096-9071
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2017
ZDB Id:
752392-0
ZDB Id:
1475090-9