In:
Journal of Medical Virology, Wiley, Vol. 95, No. 1 ( 2023-01)
Kurzfassung:
Hydrogen sulfide (H 2 S) is a redox gasotransmitter. It has been shown that H 2 S has a key role in host antiviral defense by inhibiting interleukin production and S‐sulfhydrating Keap1 lead to Nrf2/ARE pathway activation. However, it is yet unclear whether H 2 S can play an antiviral role by regulating autophagy. In this study, we found that exogenous H 2 S decreased the expression of human T‐cell leukemia virus type‐1 (HTLV‐1) protein and HTLV‐1 induced autophagosomes accumulation. Transmission electron microscope assays indicated that autophagosomes accumulation decreased after H 2 S administration. HTLV‐1‐transformed T‐cell lines had a high level of CSE (H 2 S endogenous enzyme) which could be induced in Hela by HTLV‐1 infection. Immunoblot demonstrated that overexpression of CSE inhibited HTLV‐1 protein expression and autophagy. And we got the opposite after CSE knockdown. Meanwhile, H 2 S could not restrain the autophagy when ATG4B had a mutant at its site of 89. In a word, these results suggested that H 2 S modulated HTLV‐1 protein expression via ATG4B. Therefore, our findings suggested a new mechanism by which H 2 S defended against virus infection.
Materialart:
Online-Ressource
ISSN:
0146-6615
,
1096-9071
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2023
ZDB Id:
752392-0
ZDB Id:
1475090-9