In:
Journal of Basic Microbiology, Wiley, Vol. 46, No. 6 ( 2006-12), p. 504-512
Kurzfassung:
An extensive screening study for the production of proteolytic inhibitors has been carried out on 75 Streptomyces strains. It was found that 18 of the strains and/or their variants (24%) produced proteinaceous substances, which belonged to the group of typical serine protease inhibitors. 23 samples were tested for inhibitory activity on the replication of influenza virus A/Germany/34, strain Rostock (H7N1) (A/Rostock) in chicken embryonic fibroblast (CEF) cells. Eleven of the tested samples (52.2%) significantly inhibited viral growth. Further the specific inhibitory effect on the replication of influenza virus A/Aichi/2/68 (H3N2) (A/Aichi) in Madin‐Darby canine kidney (MDCK) cells and on the growth of herpes simplex virus type 1, strain DA (HSV‐1) in Madin‐Darby bovine kidney (MDBK) cells was tested. Nine samples significantly inhibited A/Aichi and four – HSV‐1. The most effective inhibitors, produced by Streptomyces sp. 225b (SS 225b) and Streptomyces chromofuscus 34‐1 (SS 34‐1) protected mice from mortality in the experimental influenza A/Aichi virus infection. (© 2006 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Materialart:
Online-Ressource
ISSN:
0233-111X
,
1521-4028
DOI:
10.1002/jobm.200510127
Sprache:
Englisch
Verlag:
Wiley
Publikationsdatum:
2006
ZDB Id:
1480967-9
ZDB Id:
632513-0
ZDB Id:
203025-1
SSG:
12
