In:
Journal of Orthopaedic Research, Wiley, Vol. 31, No. 2 ( 2013-02), p. 300-305
Abstract:
The purpose was to evaluate histological changes of the supraspinatus tendon (SSP) after refixation under continuous growth factor application over 20 days in comparison to the native healing process. In a chronic rat tendon tear model (15 rats/group), a transosseous SSP refixation was performed and growth factors (control, G‐CSF, b‐FGF, combination) were continuously released into the subacromial space by an osmotic pump. Tendon healing was evaluated histologically by a modified MOVIN‐Score, and Collagen I/III content was determined by immunohistology at 6 weeks. A modified MOVIN sum score showed significant lower counts for G‐CSF and b‐FGF in comparison to the control group ( p = 0.050/ p = 0.027) and the combined group ( p = 0.050/ p = 0.043). Collagen III was significantly reduced in the combined group compared to the control group ( p = 0.028). Collagen I showed no significant differences. The Collagen I/III ratio was nearly doubled for b‐FGF and the combined group compared to the control. At the study endpoint, 33% of pump dislocations were detected. The continuous application of both isolated growth factors (G‐CSF/b‐FGF) achieved improved tendon‐remodeling. However, the continuous application via an osmotic pump showed a relative high dislocation rate when applied in the rat model. © 2012 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31: 300–305, 2013
Type of Medium:
Online Resource
ISSN:
0736-0266
,
1554-527X
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2050452-4