In:
Journal of Surgical Oncology, Wiley, Vol. 103, No. 1 ( 2011-01), p. 10-16
Abstract:
The feasibility and safety of oxaliplatin‐based hyperthermic intraperitoneal chemotherapy (HIPEC) associated with cytoreductive surgery (CRS) was assessed in patients with peritoneal carcinomatosis resulting from primary advanced or relapsing epithelial ovarian cancer (EOC). Methods Thirty‐one patients received neoadjuvant platin‐based chemotherapy followed by oxaliplatin‐based HIPEC associated with CRS as consolidation of primary therapy (n = 19) or for relapsing disease (n = 12). Grade 3/4 complications were recorded according to National Cancer Institute definitions. Results Median peritoneal carcinomatosis index (PCI) was 2.7 after neoadjuvant chemotherapy. Mean duration of surgery was 352 min (range 105–614) and median hospital stay was 11 days (range 6–87). Grade 3 toxicity was observed in nine patients: five required repeat surgery, two an invasive procedure, four rehospitalization, and three a return to the ICU. No grade 4 toxicity occurred, excepted one hypokalemia. Median progression‐free survival (PFS) for primary advanced EOC was 13.2 months and 1‐year PFS was 59.3%. Median PFS for relapsing patients was 14.3 months and 1‐year PFS was 54.4%. Conclusion CRS with oxaliplatin‐based HIPEC is feasible and relatively safe in recurrent and primary EOC. HIPEC after neoadjuvant chemotherapy reduces the PCI and decreases the number of surgical procedures and morbidity. Further evaluations of this procedure are required to assess the survival benefits. J. Surg. Oncol. 2011;103:10–16. © 2010 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
0022-4790
,
1096-9098
Language:
English
Publisher:
Wiley
Publication Date:
2011
detail.hit.zdb_id:
1475314-5
